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KMID : 1123920050190010242
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Korean Journal of Oriental Physiology and Pathology
2005 Volume.19 No. 1 p.242 ~ p.245
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Potential Role of Anti-inflammation by Red Ginseng in Rat Microglia
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Yoo Yeong-Min
Joo Seong-Soo
Lee Seon-Goo
Lee Do-Ik
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Abstract
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The most common feature of neurodegenerative disease (i.e. Alzheimer’s disease, AD) is the increased number of activated microglial cells nearby the pathogenic area of the brain, such as amyloid plaque in AD. An abnormality of protein regulation and an imbalance of clearance against produced amyloid precursor protein (APP) can turn microglia into the activated feature out of the ramified resting phase. We examined the possibility that ginsenoside Rb1 could attenuate the microglial activation induced by massive that has known to induce a chronic inflammation, which is a major cause of AD by damaging neuronal cells (i.e. apoptosis or necrosis). Aggregated peptide was used with lipopolysaccharide (LPS) () for a comparative control up to 48hours. We found that Rb1 reduced the production of nitric oxide as well as proinflammatory cytokines, such as and .
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KEYWORD
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Alzheimer’s disease, ginsenoside Rb1, lipopolysaccharide
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